منابع مشابه
Studies of Antimetabolites* Ii. I-acetylpyridine
When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...
متن کاملStudies of antimetabolites. II. 3-Acetylpyridine.
When 3acetylpyridine (3-AP) is fed to dogs, large amounts of a normal end-product of nicotinic acid metabolism, N’-methylnicotinamide (NMeN), appear in the urine (1). This finding might be interpreted as evidence that 3-AP, acting as an antivitamin, displaces nicotinamide from its nucleotides or prevents its incorporation therein, or, alternatively, that 3-AP is biologically oxidized to nicotin...
متن کاملA Study of Antimetabolites
Pettus gave everything he had as a medical missionary in China and Dr. Edward H. Hume has drawn a clear and sympathetic picture of this man, his aspirations, and those qualities which distinguished him as a medical scientist at home and abroad. On 23 November 1945 was received the melancholy cablegram from Huangping, China, which read as follows: "Dr. Pettus killed in airplane accident at Huang...
متن کاملpostnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
Problems in the Designing of Antimetabolites †
Historically, the most useful medicinal agents have been obtained by empirical screening or by the chemical modification of compounds of known activity in the hope of making them more effective. To these approaches a new one was added in recent years-antimetabolites. An antimetabolite may be defined as a compound bearing structural resemblance to a metabolite and capable of being attached to th...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1953
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)77276-7